Conventional treatment was defined as the ordinary therapy including fluid resuscitation, nutrition support, antibiotic therapy, and other organ support in the intensive care unit but with no forms of extracorporeal treatment.
All other statistical analyses were performed by using Review Manager, version 5. We limited article types to randomized controlled trials, and because sepsis in children is different in terms of infectious etiology and host response, we only included adults more than 18 years of age.
Sepsis involves complex interactions between endothelial cells, platelets, leukocytes, coagulation system, and multiple pro- and anti-inflammatory mediators, and often results in multiple organ dysfunction syndrome MODS leading to death 56. We categorized trials according to the type of blood purification technique used.
In addition, we also assessed the modality of blood purification, as well as the comparisons or related description of primary outcome between blood purification and conventional treatment, such as mortality or physiologic variables.
Data Extraction Two authors independently selected studies and extracted data.
With the recent removal of Xigris, the only FDA-approved treatment for Peng plasma analysis, from the market due to failure to show a survival benefit for patients with septic shock 3the medical community is urgently seeking a possible therapy.
For each study raw data were extracted using a standard form, which included the first author, study design, Peng plasma analysis of publication, total number of patients, patient characteristics, details regarding the outcomes and types of sepsis.
We assessed publication bias by evaluating the funnel plots i. Source control and antibiotics remain the mainstays of therapy for infection 4 but no specific treatment is available for sepsis.
Quality Assessment We assessed quality of each study included in the meta-analysis using the Jadad score 18which assesses the conduct of randomization, concealment of treatment allocation, similarity of treatment groups at baseline, clinician blinding, and the description of withdrawals and dropouts.
Therefore we performed a systematic review and meta-analysis to attempt to determine whether blood purification decreases mortality in patients with sepsis so as to guide further research in this area.
Data Synthesis Overall, blood purification decreased mortality compared to no blood purification If mortality was assessed at several time points in a study, we used data from the latest follow-up time for overall mortality assessment.
To further ascertain what factors may have influenced treatment effects, we performed a variety of sensitivity analyses to determine the RR of death within particular groups: We conducted a systematic review and meta-analysis of randomized trials to determine the association between various blood purification techniques and all-cause mortality in humans with sepsis.
Subsequently, we carefully read the full-text of each of the remaining 36 trials and excluded 20 trials: Summary statistics, risk ratios RRsand CIs were calculated using random-effects modeling. Observations over more than 20 years have suggested a role for extracorporeal blood purification.
These results were mainly influenced by studies using polymyxin B hemoperfusion from Japan. Search was performed using medical subject heading MeSH terms and text words with Boolean strategy, and cross-searching of the following 3 categories: Because the random effects model incorporates statistical heterogeneity and provides a more conservative estimate of the pooled effect size compared to the fixed model, we present the results of all analyses according to a random effects model by using the method of DerSimonian and Laird that considers both within study and between-study variation Unlike drugs targeting specific mediators, blood purification can influence a wide range of molecules.
However, these results were driven mainly by hemoperfusion RR, 0. The bibliographies of all relevant studies and recent review articles were scanned to identify additional citations.Peng Zhang, “Effects of non-linear quantum electrodynamics on ultra-relativistic laser-plasma interaction”, EPD Research Seminar, Singapore University of Technology and Design, Singapore, 10/08/ Analysis and stability of retinol in plasma.
Peng YM, Xu MJ, Alberts DS.
A simple, precise, and specific high-performance liquid chromatography (HPLC) method was developed for the simultaneous measurement of retinol (ROH), 13. Although blood purification improves outcomes in animal studies of sepsis, results of clinical trials have been mixed.
We conducted a systematic review and meta-analysis of randomized trials to determine the association between various blood purification techniques and all-cause mortality in humans.
Peng Plasma Solutions Strategic Financial Analysis After reading the case on Peng Plasma Solutions and reviewing the financials we have identified 3 major problems that have occurred due to a number of factors.
After reading the case on Peng Plasma Solutions and reviewing the financials we have identified 3 major problems that have occurred due to a number of factors.
Peng Zhang’s research interests are in theory and modeling of nanoelectronics, electromagnetic fields and waves, plasmas, and accelerator technology.Download